Whitehouse Station, NJ 08889, USA. Kooyman AR, Zwart R, Vanderheijden PM, Van Hooft JA, Vijverberg HP 1994. "Interaction between enantiomers of mianserin and ORG3770 at 5-HT 3 receptors in cultured mouse neuroblastoma cells". Neuropharmacology. Combined use of St. John's wort with benzodiazepines may increase side effects such as dizziness, drowsiness, impaired thinking and difficulty concentrating. You should avoid or limit the use of alcohol while being treated with these medications. Avoid driving or operating hazardous machinery until you know how the medications affect you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. mail order topamax online visa
Remeron, compared to 7% for placebo and 8% for amitriptyline. Antidepressants increased the risk compared to placebo of suicidal thinking and behavior suicidality in children, adolescents, and young adults in short-term studies of major depressive disorder MDD and other psychiatric disorders. Body as a Whole: frequent: malaise, abdominal pain, abdominal syndrome acute; infrequent: chills, fever, face edema, ulcer, photosensitivity reaction, neck rigidity, neck pain, abdomen enlarged; rare: cellulitis, chest pain substernal.
The concomitant use of Brintellix with MAOIs intended to treat psychiatric disorders is contraindicated. Brintellix should also not be started in a patient who is being treated with MAOIs such as linezolid or intravenous methylene blue. Kor, Ariel. Sexual Addict Compulsivity, published online April 9, 2013. Abo-Zena RA, Bobek MB, Dweik RA April 2000. "Hypertensive urgency induced by an interaction of mirtazapine and clonidine". Pharmacotherapy. What about sexual dysfunction related to antidepressants? Symptoms may include diarrhea.
FDA pregnancy category D. Do not use Xgeva if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment. Gardner, E. M. Supplementation with active hexose correlated compound increases the innate immune response of young mice to primary influenza infection. J Nutr. Digestive System: frequent: vomiting, anorexia; infrequent: eructation, glossitis, cholecystitis, nausea and vomiting, gum hemorrhage, stomatitis, colitis, liver function tests abnormal; rare: tongue discoloration, ulcerative stomatitis, salivary gland enlargement, increased salivation, intestinal obstruction, pancreatitis, aphthous stomatitis, cirrhosis of liver, gastritis, gastroenteritis, oral moniliasis, tongue edema.
The pooled analyses of placebo-controlled trials in children and adolescents with MDD, obsessive compulsive disorder OCD or other psychiatric disorders included a total of 24 short-term trials of 9 antidepressant drugs in over 4400 patients. Sedation and inability to suckle have occurred in neonates of lactating mothers taking benzodiazepines. Infants of lactating mothers should be observed for pharmacological effects including sedation and irritability. Patients should not stop using any medications without first talking to their doctor. While studies show that TMS can help, it has not been proven to be as effective as ECT in controlling depression. Researchers are still trying to sort out who might be most likely to benefit from it. As of now, they believe that TMS might work best in people with moderate symptoms who have only had one unsuccessful round of treatment with an antidepressant. When phenytoin, carbamazepine, or another inducer of hepatic metabolism such as rifampicin is added to mirtazapine therapy, the mirtazapine dose may have to be increased. If treatment with such a medicinal product is discontinued, it may be necessary to reduce the mirtazapine dose. Perlis says. “But it also appears to perpetuate depression. Many drugs can interact with mirtazapine. Below is just a partial list.
Take REMERON exactly as prescribed. Your healthcare provider may need to change the dose of REMERON until it is the right dose for you. Diabetes patients - Use a form of cranberry that is sugar-free. Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical studies of another drug and may not reflect the rates observed in clinical practice. Wakame, K. Prevention of Cancer and Radiation Induced Disorders by Active Hexose Correlated Compound, AHCC in Mice and Humans. Presented at the 20th International Congress on Nutrition and Integrative Medicine ICNIM 2012. Fawcett J, Barkin RL December 1998. "Review of the results from clinical studies on the efficacy, safety and tolerability of mirtazapine for the treatment of patients with major depression". Journal of Affective Disorders. At least 14 days should elapse between discontinuation of an MAOI intended to treat psychiatric disorders and initiation of therapy with REMERON mirtazapine Tablets. Use Dulcolax as directed by your doctor. Check the label on the medicine for exact dosing instructions. If either of these effects persists or worsens, tell your doctor or promptly. To reduce the risk of dizziness or falling, get up slowly when rising from a sitting or lying position. If concomitant use of REMERON with other serotonergic drugs, including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, buspirone, tryptophan, and St. John's wort, is clinically warranted, be aware of a potential increased risk for serotonin syndrome, particularly during treatment initiation and dose increases. MAO inhibitor and a tricyclic. pletal
In contrast to mirtazapine, the SSRIs, SNRIs, MAOIs, and some TCAs increase the general activity of the 5-HT 2A, 5-HT 2C, and 5-HT 3 receptors leading to a host of negative changes and side effects, the most prominent of which including anorexia, insomnia, sexual dysfunction loss of and nausea, and diarrhoea, among others. As a result, it is often combined with these drugs to reduce their side-effect profile and to produce a stronger antidepressant effect. There are no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Continued How Do Antidepressants Relieve Depression In the Elderly? The Pharmacological Basis of Therapeutics, New York, 1980, Macmillan Publishing. Patients should be advised to inform their physician if they are taking, or intend to take, any prescription or over-the-counter drugs, since there is a potential for REMERON to interact with other drugs. Peter C, Hongwan D, Kupfer A, Lauterburg BH. Pharmacokinetics and organ distribution of intravenous and oral methylene blue. The results are more similar to those seen in sleeping pills and other medications designed specifically to help sleep. Brunton, L; Chabner, B; Knollman, B 2010. MRHD, respectively in the presence of maternal toxicity decreased food consumption and decreased body weight gain. Montgomery and Asberg Depression Rating Scale MADRS. online omeprazole bula omeprazole
CGI-Improvement score of 1 or 2 at 2 consecutive visits beginning with week 6 of the 8 to 12 weeks in the open-label phase of the study. Relapse during the double-blind phase was determined by the individual investigators. Patients receiving continued Remeron treatment experienced significantly lower relapse rates over the subsequent 40 weeks compared to those receiving placebo. This pattern was demonstrated in both male and female patients. Starch corn hydroxypropyl cellulose, magnesium stearate, colloidal silicon dioxide, lactose, hypromellose, polyethylene glycol 8000, titanium dioxide, ferric oxide yellow. If you notice a sudden change in bowel habits that lasts for 2 weeks or more, do not continue using Dulcolax. Instead, check with your doctor. Because voluntarily reported adverse sexual reactions are known to be underreported, in part because patients and physicians may be reluctant to discuss them, the Arizona Sexual Experiences Scale ASEX a validated measure designed to identify sexual side effects, was used prospectively in seven placebo-controlled trials. The ASEX scale includes five questions that pertain to the following aspects of sexual function: 1 sex drive, 2 ease of arousal, 3 ability to achieve erection men or lubrication women 4 ease of reaching orgasm, and 5 orgasm satisfaction. Cerrand, C. Plastic and Reconstructive Surgery, December 2006. Kast RE September 2001. "Mirtazapine may be useful in treating nausea and insomnia of cancer chemotherapy". Supportive Care in Cancer. The effect of REMERON mirtazapine on QTc interval was assessed in a clinical randomized trial with placebo and positive moxifloxacin controls involving 54 healthy volunteers using exposure response analysis. This trial showed a positive relationship between mirtazapine concentrations and prolongation of the QTc interval. However, the degree of QT prolongation observed with both 45 mg therapeutic and 75 mg supratherapeutic doses of mirtazapine was not at a level generally considered to be clinically meaningful. Families and caregivers of patients being treated with antidepressants for major depressive disorder or other indications, both psychiatric and nonpsychiatric, should be alerted about the need to monitor patients for the emergence of agitation, irritability, unusual changes in behavior, and the other symptoms described above, as well as the emergence of suicidality, and to report such symptoms immediately to health care providers. Such monitoring should include daily observation by families and caregivers. Prescriptions for REMERON mirtazapine Tablets should be written for the smallest quantity of tablets consistent with good patient management, in order to reduce the risk of overdose. What specialists treat depression? Rectal bleeding or failure to have a bowel movement within 12 hours after use of a laxative may be a sign of a serious condition. Stop use and contact your doctor. What should I discuss with my healthcare provider before taking mirtazapine Remeron? Kwon, A. Occurrence of Hydrophilic Hepato-protective Compounds in AHCC in Addition to Adenosine. Presented at the 20th International Congress on Nutrition and Integrative Medicine ICNIM 2012. store xeloda buy
It is not known whether denosumab passes into breast milk or if it could harm a nursing baby. However, this medication may slow the production of breast milk. You should not breast-feed while receiving Xgeva. Iwase, S. Exploratory Clinical Research on Active Hexose Correlated Compound AHCC: Effect of AHCC on Patients with Breast Cancer Treated with Adjuvant Chemotherapy. Presented at the 19th International Congress on Nutrition and Integrative Medicine ICNIM 2011. Get emergency medical help if you have any of these signs of an allergic reaction: skin rash or hives; difficulty breathing; swelling of your face, lips, tongue, or throat. You should check your blood pressure regularly. Tell your doctor if there is a change in your blood pressure, since he may need to change the dose of your medicine depending on your blood pressure. You should also tell your doctor if you have any chest pain or shortness of breath, or if you have any dizziness, headache, or blurred vision. Nutritional counseling. A registered dietitian will help you take charge of your weight in a healthy way. The European Journal of Neuroscience, October 2011. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Chemokine mRNA in Rat Hepatocytes. Presented at the 20th International Congress on Nutrition and Integrative Medicine ICNIM 2012. In the 6-month, double-blind, placebo-controlled phase of a long-term study in patients who had responded to Brintellix during the initial 12-week, open-label phase, there were no clinically important changes in lab test parameters between Brintellix and placebo-treated patients. The impairment of cognitive and motor skills produced by Remeron has been shown to be additive with those produced by alcohol. Accordingly, patients should be advised to avoid alcohol while taking mirtazapine. Ask your healthcare provider if you are not sure if you are taking any of these medicines. REMERON has been shown to be additive with those produced by alcohol. It is common for antidepressant medicines such as Remeron to take up to a few weeks before you start to feel better. Do not stop taking Remeron if you do not feel results right away. HT3, 5-HT1D, and 5-HT7 receptor antagonist, 5-HT1B receptor partial agonist, and 5-HT1A receptor agonist. adol.info sotalol
All other trademarks are the property of their respective owners. Because some REMERON may be excreted into breast milk, caution should be exercised when REMERON mirtazapine Tablets are administered to nursing women. REMERON. See the end of this Medication Guide for a complete list of ingredients in REMERON. Hisajima, T. The Effects of AHCC on the Autonomic Nervous Function. Presented at the 20th International Congress on Nutrition and Integrative Medicine ICNIM 2012. Wakame, K. Evaluation of AHCC for Quality of Life QOL as Integrative Medicine during Treatment of Advanced Head and Neck Cancer Patients. Presented at the 20th International Congress on Nutrition and Integrative Medicine ICNIM 2012. Kamiyama, Y. Improved prognosis of postoperative hepatocellular carcinoma patients when treated with functional foods: a prospective cohort study. J Hepatol. However, these drugs may cause you to feel sleepy during the day and can also cause dependence, meaning you may always need to be on the drug to be able to sleep. Brintellix is an immediate-release tablet for oral administration that contains the beta β polymorph of vortioxetine hydrobromide HBr an antidepressant. US Food and Drug Administration FDA. Read the Guide provided by your before you start using and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Most of the available are believed to be equally effective in elderly adults. But the risk of side effects or potential reactions with other medicines must be carefully considered. Therapy. Talking with a psychologist or mental health professional will help you cope with the emotional reasons behind anorexia. For example, you may discuss life stresses, unhelpful beliefs about food and weight, or certain personality traits that may be, in part, causing anorexia.
Only some people are at risk for these problems. You may want to undergo an eye examination to see if you are at risk and receive preventative treatment if you are. 6. Seizures 7. Low salt sodium levels in the blood. Elderly people may be at greater risk for this. For that reason, it is important to make sure that an elderly person you are concerned about is evaluated and treated, even if the depression is mild. Is mirtazapine available as a generic drug? Hydroxyzine may affect your heart's rhythm. Other drugs can have the same effect. AUC of a single 30-mg dose of mirtazapine by approximately 40% and 50%, respectively. The efficacy of Brintellix in patients aged 18 years to 75 years was demonstrated in five 6 to 8 week, placebo-controlled studies Studies 1 to 5 in Table 4. In these studies, patients were randomized to Brintellix 5 mg, 10 mg, 15 mg or 20 mg or placebo once daily. CNS reactions possible when linezolid Zyvox is given to patients taking certain psychiatric medications. AHCC to Dairy Calves prior Weaning on Respiratory Afflictions and Immune Response during the Postweaning Period. Presented at the 18th International Congress on Nutrition and Integrative Medicine ICNIM 2010. Brayfield, A, ed. 30 January 2013. Colfax GN, Santos GM, Das M, Santos DM, Matheson T, Gasper J, Shoptaw S, Vittinghoff E November 2011. Nude Mice. Presented at the 19th International Congress on Nutrition and Integrative Medicine ICNIM 2011. REMERON may be taken with or without food. buy dapoxetine mastercard canada
Who should not take Remeron? Check with your carrier to learn about your coverage. Goodnick PJ, Puig A, DeVane CL, Freund BV July 1999. "Mirtazapine in major depression with comorbid generalized anxiety disorder". The Journal of Clinical Psychiatry. Now doctors also use them to prevent and treat skeletal problems from bone metastases. They decrease pain while reducing bone damage and risk for fracture. They also lower levels of that may be too high. They are usually given to cancer patients by intravenous IV infusion. Clinical experience with REMERON in patients with concomitant systemic illness is limited. Accordingly, care is advisable in prescribing mirtazapine for patients with diseases or conditions that affect metabolism or hemodynamic responses. This may make you sleepy during the day. Tell your doctor if you have daytime drowsiness. Your dose may need to be adjusted. Ongoing chronic forms of anorexia may require treatment for many years, including hospitalizations when needed. Ongoing treatment usually includes psychological counseling. There have been reports of adverse reactions upon the discontinuation of REMERON mirtazapine Tablets particularly when abrupt including but not limited to the following: dizziness, abnormal dreams, sensory disturbances including paresthesia and electric shock sensations agitation, anxiety, fatigue, confusion, headache, tremor, nausea, vomiting, and sweating, or other symptoms which may be of clinical significance. The majority of the reported cases are mild and self-limiting. Even though these have been reported as adverse reactions, it should be realized that these symptoms may be related to underlying disease. Patients should be advised to notify their physician if they are breastfeeding an infant. Even those who take lower doses should be cautioned about possible sleepiness the next day, because individuals have different sensitivities to drugs, the agency noted. If any close relatives had depression, what medication worked for them? Fernández J, Alonso JM, Andrés JI, Cid JM, Díaz A, Iturrino L, Gil P, Megens A, Sipido VK, Trabanco AA March 2005. "Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents". Journal of Medicinal Chemistry. epogen shopping
Wakame K. Protective Effects of Active Hexose Correlated Compound AHCC on the Onset of Diabetes Induced by Streptozotocin in the Rat. Fighting this process is a critical aspect of treatment. American Geriatric Society, pose an increased risk for impaired alertness, respiratory depression, and falls. When they work properly, they help to relieve symptoms and, along with other approaches such as talk therapy, are an important part of treatment. Table 3 shows the incidence of patients that developed treatment-emergent sexual dysfunction when treated with Brintellix or placebo in any fixed dose group. Physicians should routinely inquire about possible sexual side effects. Kulkarni, A. D. AHCC Positively Regulates Liver Metabolism by Diminishing Oxidative Stress and Protects the Heart by Increasing Liver Trafficking of LDL. Presented at the 20th International Congress on Nutrition and Integrative Medicine ICNIM 2012. Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. letrozole
The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using mirtazapine, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain problems , slow heartbeat, QT prolongation in the family history of certain heart problems QT prolongation in the EKG, sudden cardiac death. Important: The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, blogs, or WebMD Answers are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. HBr equivalent to 5 mg, 10 mg, 15 mg, or 20 mg of vortioxetine, respectively. The inactive ingredients in Brintellix tablets include mannitol, microcrystalline cellulose, hydroxypropyl cellulose, sodium starch glycolate, magnesium stearate and film coating which consists of hypromellose, titanium dioxide, polyethylene glycol 400, iron oxide red 5 mg, 15 mg, and 20 mg and iron oxide yellow 10 mg and 15 mg. Zofran ondansetron US prescribing information. Torrado-Duran, J. J. Effect of AHCC on the Anthelmintic Activity of Albendazole. Presented at the 20th International Congress on Nutrition and Integrative Medicine ICNIM 2012. General information about the safe and effective use of REMERON. Under the direction of a physician, certain benzodiazepines may be given in very serious and life-threatening situations like status epilepticus. Do not start Brintellix if you stopped taking an MAOI in the last 14 days. Amitriptyline hydrochloride, US prescribing information. Sandoz Inc. January, 2010. Tatsumi M, Groshan K, Blakely RD, Richelson E December 1997. Sun, B. Nutritional Food Active Hexose Correlated Compound AHCC Enhances Resistance Against Bird Flu. Japanese Journal of Complimentary and Alt. zestoretic
If any of these effects persist or worsen, tell your doctor or promptly. Do not start REMERON if you stopped taking an MAOI in the last 2 weeks unless directed to do so by your healthcare provider. REMERON mirtazapine Tablets are contraindicated in patients with a known hypersensitivity to mirtazapine or to any of the excipients. Your counselor can help you at those times when it is hard to follow healthy ways of thinking about food and your body. Patients should be made aware of a potential increased risk for serotonin syndrome if concomitant use of Remeron with other serotonergic drugs, including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, buspirone, tryptophan, and St. John's wort, is clinically warranted, particularly during treatment initiation and dose increases. In premarketing clinical trials, only 1 seizure was reported among the 2796 US and non-US patients treated with Remeron. However, no controlled studies have been carried out in patients with a history of seizures. Therefore, care should be exercised when mirtazapine is used in these patients. REMERON is a prescription medicine used to treat depression. I've become married, bought a house, and am excited to live again! Follow your doctor's instructions about any restrictions on food, beverages, or activity. There have been no clinical studies to evaluate the effect of race on the pharmacokinetics of Remeron. Before taking mirtazapine, tell your doctor if you have bipolar disorder, liver or kidney disease, seizures, heart disease, a history of heart attack or stroke, or a history of drug abuse or suicidal thoughts. Women who discontinued antidepressant medication during pregnancy showed a significant increase in relapse of their major depression compared to those women who remained on antidepressant medication throughout pregnancy. When treating a pregnant woman with Brintellix, the physician should carefully consider both the potential risks of taking a serotonergic antidepressant, along with the established benefits of treating depression with an antidepressant.
Timmer CJ, Sitsen JM, Delbressine LP June 2000. It may harm an unborn baby. If you are a woman of childbearing age, use a reliable form of while taking this drug. If you are planning pregnancy, do not take this medication. If you become or think you may be pregnant, tell your doctor right away. Antidepressants may take longer to start working in older people than they do in younger people. Since elderly people are more sensitive to medicines, doctors may prescribe lower doses at first. In general, the length of treatment for depression in the elderly is longer than it is in younger patients. Can Psychotherapy Help Relieve Depression In the Elderly? Events reported by at least 1% of patients treated with REMERON are included, except the following events, which had an incidence on placebo greater than or equal to REMERON: headache, infection, pain, chest pain, palpitation, tachycardia, postural hypotension, nausea, dyspepsia, diarrhea, flatulence, insomnia, nervousness, libido decreased, hypertonia, pharyngitis, rhinitis, sweating, amblyopia, tinnitus, taste perversion. Gargle and rinse your with water after each use of this medication to help prevent dryness, irritation, and in the and throat. Do not swallow the rinse water. Smith, J. Evaluation of active hexose correlated compound hepatic metabolism and potential for drug interactions with chemotherapy agents. J Soc Integr. PREGNANCY and BREAST-FEEDING: If you plan on becoming pregnant, discuss with your doctor the benefits and risks of using this product during pregnancy. If you are or will be breast-feeding while you are using this product, check with your doctor or pharmacist to discuss the risks to your baby. Brackins T, Brahm NC, Kissack JC December 2011. "Treatments for methamphetamine abuse: a literature review for the clinician". Journal of Pharmacy Practice. Xgeva denosumab is a monoclonal antibody. Monoclonal antibodies are made to target and destroy only certain cells in the body. This may help to protect healthy cells from damage. Smith, J. A. Evaluation of active hexose correlated compound AHCC in combination with pegylated liposomal doxorubicin for treatment of ovarian cancer. Cardiovascular System: frequent: hypertension, vasodilatation; infrequent: angina pectoris, myocardial infarction, bradycardia, ventricular extrasystoles, syncope, migraine, hypotension; rare: atrial arrhythmia, bigeminy, vascular headache, pulmonary embolus, cerebral ischemia, cardiomegaly, phlebitis, left heart failure. In the elderly, often occurs with other medical illnesses and disabilities and lasts longer. Your doctor will consider many factors when determining your treatment options. One is the location of the pain. For example, metastasis in a -bearing bone is more painful than in other bones, Fasano says. This may affect the approach to treatment. The disposition of mirtazapine was studied in patients with varying degrees of renal function. Elimination of mirtazapine is correlated with creatinine clearance. If you can't eat, you are given your in fluid form. buy minocycline tabletas
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The primary efficacy measures were the Hamilton Depression Scale HAMD-24 total score in Study 2 and the Montgomery-Asberg Depression Rating Scale MADRS total score in all other studies. In each of these studies, at least one dose group of Brintellix was superior to placebo in improvement of depressive symptoms as measured by mean change from baseline to endpoint visit on the primary efficacy measurement see Table 4. Subgroup analysis by age, gender or race did not suggest any clear evidence of differential responsiveness. Keep all follow-up visits with your healthcare provider and call between visits if you are worried about symptoms.
Ultram tramadol US prescribing information. Janssen Pharmaceutical, Inc. When you're trying a new drug for treatment-resistant depression, make sure to give it a fair chance. Cook says that many people who think they are treatment-resistant -- because they've tried a number of antidepressants without success -- might not be. Instead, they just weren't on the medicine long enough to know one way or another. Side effects are often the reason. Muehlbacher M, Nickel MK, Nickel C, Kettler C, Lahmann C, Pedrosa Gil F, Leiberich PK, Rother N, Bachler E, Fartacek R, Kaplan P, Tritt K, Mitterlehner F, Anvar J, Rother WK, Loew TH, Egger C December 2005.
Use of this medication is usually limited to short treatment periods of 1 to 2 weeks or less. If your continues for a longer time, talk to your doctor to see if you need other treatment. Sometimes there are pretty striking weight gains. The latest findings have helped improve treatment strategies. Evidence shows that treating sleep problems can ease depressive symptoms and may even prevent relapses. In one study, 56 people who suffered both depression and insomnia received psychotherapy for their sleep problems alone. The eased in more than half of the people, even though their treatment had not targeted depression.
Week 8 and 15% for at least 8 weeks since Week 4. Patients on Brintellix experienced a statistically significantly longer time to have recurrence of depressive episodes than did patients on placebo. Gave one star to Zoloft for its effort, but really it deserves zero stars from my experience. I was on Remeron, then Cipralex Lexapro for American users for almost a year and when it stopped working I decided to go with Zoloft after reading good reviews. Zoloft slowly turned me into the worst version of myself. It is prescribed for people who have difficulty falling asleep. can be prescribed for long-term use, and the drug has shown no evidence of abuse or dependence.